Article
A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.
Nature cell biology - 1 Feb 2016
Buono Mario, Facchini Raffaella, Matsuoka Sahoko, Thongjuea Supat, Waithe Dominique, Luis Tiago C, Giustacchini Alice, Besmer Peter, Mead Adam J, Jacobsen Sten Eirik W, Nerlov Claus
Abstract excerpt
Thymic T cell development is initiated from bone-marrow-derived multi potent thymus-seeding progenitors. During the early stages of thymocyte differentiation, progenitors become T cell restricted. However, the cellular environments supporting these critical initial stages of T cell development within the thymic cortex are not known. Here we use the dependence of early, c-Kit-expressing thymic progenitors on Kit...
Topics
- Animals
- Cell Differentiation
- Cell Lineage
- Cell Movement
- Cells, Cultured
- Coculture Techniques
- Endothelial Cells
- Gene Expression Regulation, Developmental
- Mice, Transgenic
- Multipotent Stem Cells
- Paracrine Communication
- Phenotype