Article
MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus.
Nature - 4 Mar 1993
Anderson G, Jenkinson E J, Moore N C, Owen J J
Abstract excerpt
T lymphocytes are produced in the thymus from precursors originating in the haemopoietic tissues. On entering the thymus, they undergo a programme of proliferation, T-cell receptor (TCR) gene rearrangement, differentiation and repertoire selection. Although the thymus provides a unique environment for these events, the role of the thymic stroma in regulating specific developmental stages is not well understood....
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