Article
Conserved cysteine residues within the attachment G glycoprotein of respiratory syncytial virus play a critical role in the enhancement of cytotoxic T-lymphocyte responses.
Virus genes - 1 Feb 2011
Melendi Guillermina A, Bridget Dowd, Monsalvo Ana C, Laham Federico F, Acosta Patricio, Delgado Maria Florencia, Polack Fernando P, Irusta Pablo M
Abstract excerpt
The cytotoxic T-lymphocyte (CTL) response plays an important role in the control of respiratory syncytial virus (RSV) replication and the establishment of a Th1-CD4+ T cell response against the virus. Despite lacking Major Histocompatibility Complex I (MHC I)-restricted epitopes, the attachment G glycoprotein of RSV enhances CTL activity toward other RSV antigens, and this effect depends on its conserved central...
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