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Article

Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective.

Journal of virology - 15 May 2017

Boyoglu-Barnum S, Todd S O, Meng J, Barnum T R, Chirkova T, Haynes L M, Jadhao S J, Tripp R A, Oomens A G, Moore M L, Anderson L J

Abstract excerpt

Respiratory syncytial virus (RSV) belongs to the family Paramyxoviridae and is the single most important cause of serious lower respiratory tract infections in young children, yet no highly effective treatment or vaccine is available. Through a CX3C chemokine motif (182CWAIC186) in the G protein, RSV binds to the corresponding chemokine receptor, CX3CR1. Since RSV binding to CX3CR1 contributes to disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28275196
DOI: 10.1128/JVI.02059-16
PMCID: PMC5411601

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