Article
Multiple heparin binding domains of respiratory syncytial virus G mediate binding to mammalian cells.
Archives of virology - 1 Oct 2003
Shields B, Mills J, Ghildyal R, Gooley P, Meanger J
Abstract excerpt
Respiratory syncytial virus (RSV) G glycoprotein mediates cell attachment through surface glycosaminoglycans (GAGs). Feldman et al. [10] suggested that specific basic amino acids in residues 184-198 of G defined a critical heparin binding domain (HBD). To further define the G HBD we made a series of truncated G proteins expressed in Escherichia coli. G88 (G residues 143-231), bound to HEp-2 cells in a dose...
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