Article
Identification of a common HLA-DP4-restricted T-cell epitope in the conserved region of the respiratory syncytial virus G protein.
Journal of virology - 1 Feb 2004
de Waal L, Yüksel S, Brandenburg A H, Langedijk J P M, Sintnicolaas K, Verjans G M G M, Osterhaus A D M E, de Swart R L
Abstract excerpt
The cellular immune response to respiratory syncytial virus (RSV) is important in both protection and immunopathogenesis. In contrast to HLA class I, HLA class II-restricted RSV-specific T-cell epitopes have not been identified. Here, we describe the generation and characterization of two human RSV-specific CD4(+)-T-cell clones (TCCs) associated with type 0-like cytokine profiles. TCC 1 was specific for the...
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