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Article

Experimental Glaucoma and Optic Nerve Transection Induce Simultaneous Upregulation of Proapoptotic and Prosurvival Genes

24 May 2006

Abstract excerpt

PURPOSE: To investigate changes in gene expression induced by elevated intraocular pressure (IOP) and complete optic nerve transsection (ONT) over time. METHODS: A gene array of 18 signal transduction pathways was used to examine the changes in RNA profiles of retinas post-ONT in rats. Among the seven genes that were determined to be upregulated, four were confirmed to have higher expression by semiquantitative...

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PMID: 16723461
DOI: 10.1167/iovs.05-0996

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