Article
Optimization of a Yellow fluorescent protein-based iodide influx high-throughput screening assay for cystic fibrosis transmembrane conductance regulator (CFTR) modulators.
Assay and drug development technologies - 1 Dec 2010
Sui Jinliang, Cotard Shakira, Andersen Jennifer, Zhu Ping, Staunton Jane, Lee Margaret, Lin Stephen
Abstract excerpt
Cystic fibrosis is an inherited, life-threatening disease associated with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The most common mutation, F508del CFTR, is found in 90% of CF patients. The loss of a single amino acid (phenylalanine at position 508) results in malformed CFTR with defective trafficking to the plasma membrane and impaired channel function. A functional...
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