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Article

Identification of synergistic combinations of F508del cystic fibrosis transmembrane conductance regulator (CFTR) modulators.

Assay and drug development technologies - 1 Dec 2010

Lin Stephen, Sui Jinliang, Cotard Shakira, Fung Brenda, Andersen Jennifer, Zhu Ping, El Messadi Najib, Lehar Joseph, Lee Margaret, Staunton Jane

Abstract excerpt

Cystic fibrosis (CF) is an inherited, life-threatening disease caused by mutations in the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR), an ABC transporter-class protein and ion channel that transports ions across epithelial cell membranes. The most common mutation lead...

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Source

Identifiers

PMID: 21050065
DOI: 10.1089/adt.2010.0313

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21050065-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Identification of synergistic combinations of F508del cystic fibrosis transmembrane conductance regulator (CFTR) modulators.PMID 21050065Read ↗

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