Article
Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion.
The Journal of clinical endocrinology and metabolism - 1 Jan 2011
Martinelli Carlos E, Keogh Julia M, Greenfield Jerry R, Henning Elana, van der Klaauw Agatha A, Blackwood Anthea, O'Rahilly Stephen, Roelfsema Ferdinand, Camacho-Hübner Cecilia, Pijl Hanno, Farooqi I Sadaf
Abstract excerpt
CONTEXT: Melanocortin receptor 4 (MC4R) deficiency is characterized by increased linear growth greater than expected for the degree of obesity. OBJECTIVE: The objective of the investigation was to study the somatotroph axis in obese MC4R-deficient patients and equally obese controls. PATIENTS AND METHODS: We obtained anthropometric measurements and insulin concentrations in 153 MC4R-deficient subjects and 1392...
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