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Article

Metabolic signalling to somatotrophs: Transcriptional and post-transcriptional mediators.

Journal of neuroendocrinology - 1 Nov 2020

Allensworth-James Melody L, Odle Angela K, Lim Juchan, LaGasse Alex N, Miles Tiffany K, Hardy Linda L, Haney Anessa C, MacNicol Melanie C, MacNicol Angus M, Childs Gwen V

Abstract excerpt

In normal individuals, pituitary somatotrophs optimise body composition by responding to metabolic signals from leptin. To identify mechanisms behind the regulation of somatotrophs by leptin, we used Cre-LoxP technology to delete leptin receptors (LEPR) selectively in somatotrophs and developed populations purified by fluorescence-activated cell sorting (FACS) that contained 99% somatotrophs. FACS-purified,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Leptin

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Identifiers

PMID: 32657474
DOI: 10.1111/jne.12883
PMCID: PMC8086172

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