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Article

Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians.

Diabetes - 1 Jan 2012

Thearle Marie S, Muller Yunhua L, Hanson Robert L, Mullins Meghan, Abdussamad Maryam, Tran John, Knowler William C, Bogardus Clifton, Krakoff Jonathan, Baier Leslie J

Abstract excerpt

Features of melanocortin-4 receptor (MC4R) deficiency have been observed to be more pronounced in childhood. Longitudinal data from a population-based study were used to separate the phenotypic effects of MC4R deficiency during childhood and adulthood. The MC4R exon was sequenced in 6,760 individuals of predominantly Pima Indian heritage, and discovered mutations were functionally assessed in vitro. Effects on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Diabetes Mellitus, Type 2

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Share to Receptor, Melanocortin, Type 4

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Identifiers

PMID: 22106157
DOI: 10.2337/db11-0708
PMCID: PMC3237672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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