Article
Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.
Human mutation - 1 Jun 2011
Wei Xiaomu, Moncada-Pazos Angela, Cal Santiago, Soria-Valles Clara, Gartner Jared, Rudloff Udo, Lin Jimmy C, Rosenberg Steven A, López-Otín Carlos, Samuels Yardena
Abstract excerpt
We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix...
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