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Article

Epigenetic silencing of multiple interferon pathway genes after cellular immortalization.

Oncogene - 26 Jun 2003

Kulaeva Olga I, Draghici Sorin, Tang Lin, Kraniak Janice M, Land Susan J, Tainsky Michael A

Abstract excerpt

Abrogating cellular senescence is a necessary step in the formation of a cancer cell. Promoter hypermethylation is an epigenetic mechanism of gene regulation known to silence gene expression in carcinogenesis. Treatment of spontaneously immortal Li-Fraumeni fibroblasts with 5-aza-2'-deoxycytidine (5AZA-dC), an inhibitor of DNA methyltransferase (DNMT), induces a senescence-like state. We used microarrays...

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Source

Identifiers

PMID: 12821946
DOI: 10.1038/sj.onc.1206594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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