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Article

Overexpression of the STE4 gene leads to mating response in haploid Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jan 1990

Whiteway M, Hougan L, Thomas D Y

Abstract excerpt

The STE4 gene of Saccharomyces cerevisiae encodes the beta subunit of the yeast pheromone receptor-coupled G protein. Overexpression of the STE4 protein led to cell cycle arrest of haploid cells. This arrest was like the arrest mediated by mating pheromones in that it led to similar morphological changes in the arrested cells. The arrest occurred in haploid cells of either mating type but not in MATa/MAT alpha...

Topics

Base Sequence
Cell Cycle
Fungal Proteins
GTP-Binding Proteins
Galactose
Gene Expression Regulation, Fungal
Haploidy
Molecular Sequence Data
Phenotype
Promoter Regions, Genetic
Saccharomyces cerevisiae

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Identifiers

PMID: 2104659
DOI: 10.1128/mcb.10.1.217-222.1990
PMCID: PMC360729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2104659-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Overexpression of the STE4 gene leads to mating response in haploid Saccharomyces cerevisiae.PMID 2104659Read ↗

Regulation of the yeast pheromone response pathway by G protein subunits.Semantic proximity Read ↗

STE50, a novel gene required for activation of conjugation at an early step in mating in Saccharomyces cerevisiae.Semantic proximity Read ↗

Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p.Semantic proximity Read ↗

STE2/SCG1-dependent inhibition of STE4-induced growth arrest by mutant STE4 delta C6 in the yeast pheromone response pathway.Semantic proximity Read ↗

Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway.Semantic proximity Read ↗

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.Semantic proximity Read ↗

Suppression of a dominant G-protein beta-subunit mutation in yeast by G alpha protein expression.Semantic proximity Read ↗

Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway.Semantic proximity Read ↗

Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction.Semantic proximity Read ↗

The Leu-132 of the Ste4(Gbeta) subunit is essential for proper coupling of the G protein with the Ste2 alpha factor receptor during the mating pheromone response in yeast.Semantic proximity Read ↗

Novel aspects of pheromone-induced cell-cycle arrest in yeast.Semantic proximity Read ↗

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