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Article

Chromosome band 7q34 deletions resulting in KIAA1549-BRAF and FAM131B-BRAF fusions in pediatric low-grade Gliomas.

Brain pathology (Zurich, Switzerland) - 1 Mar 2015

Roth Jacquelyn J, Santi Mariarita, Pollock Avrum N, Harding Brian N, Rorke-Adams Lucy B, Tooke Laura S, Biegel Jaclyn A

Abstract excerpt

The majority of pediatric low-grade gliomas (LGGs) are characterized by constitutive activation of the mitogen-activated protein kinase (MAPK) pathway through various mechanisms including BRAF mutations, inactivation of NF1, and KIAA1549-BRAF and FAM131B-BRAF fusions. The KIAA1549-BRAF fusion typically results from a 2.0 Mb tandem duplication in chromosome band 7q34. In the present study, single nucleotide...

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Identifiers

PMID: 25040262
DOI: 10.1111/bpa.12167
PMCID: PMC4282976

Genes

BRAF
FAM131B
KIAA1549
NF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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