Clinical impact of combined epigenetic and molecular analysis of pediatric low-grade gliomas.

doi:10.1093/neuonc/noaa077

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Article

Clinical impact of combined epigenetic and molecular analysis of pediatric low-grade gliomas.

Neuro-oncology - 14 Oct 2020

Fukuoka Kohei, Mamatjan Yasin, Tatevossian Ruth, Zapotocky Michal, Ryall Scott, Stucklin Ana Guerreiro, Bennett Julie, Nobre Liana Figueiredo, Arnoldo Anthony, Luu Betty, Wen Ji, Zhu Kaicen, Leon Alberto, Torti Dax, Pugh Trevor J, Hazrati Lili-Naz, Laperriere Normand, Drake James, Rutka James T, Dirks Peter, Kulkarni Abhaya V, Taylor Michael D, Bartels Ute, Huang Annie, Zadeh Gelareh, Aldape Kenneth, Ramaswamy Vijay, Bouffet Eric, Snuderl Matija, Ellison David, Hawkins Cynthia, Tabori Uri

Abstract excerpt

BACKGROUND: Both genetic and methylation analysis have been shown to provide insight into the diagnosis and prognosis of many brain tumors. However, the implication of methylation profiling and its interaction with genetic alterations in pediatric low-grade gliomas (PLGGs) are unclear. METHODS: We performed a comprehensive analysis of PLGG with long-term clinical follow-up. In total 152 PLGGs were analyzed from a...

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PMID: 32242226
DOI: 10.1093/neuonc/noaa077
PMCID: PMC7566385

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