Article
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.
Nature genetics - 1 Mar 2016
Bandopadhayay Pratiti, Ramkissoon Lori A, Jain Payal, Bergthold Guillaume, Wala Jeremiah, Zeid Rhamy, Schumacher Steven E, Urbanski Laura, O'Rourke Ryan, Gibson William J, Pelton Kristine, Ramkissoon Shakti H, Han Harry J, Zhu Yuankun, Choudhari Namrata, Silva Amanda, Boucher Katie, Henn Rosemary E, Kang Yun Jee, Knoff David, Paolella Brenton R, Gladden-Young Adrianne, Varlet Pascale, Pages Melanie, Horowitz Peleg M, Federation Alexander, Malkin Hayley, Tracy Adam A, Seepo Sara, Ducar Matthew, Van Hummelen Paul, Santi Mariarita, Buccoliero Anna Maria, Scagnet Mirko, Bowers Daniel C, Giannini Caterina, Puget Stephanie, Hawkins Cynthia, Tabori Uri, Klekner Almos, Bognar Laszlo, Burger Peter C, Eberhart Charles, Rodriguez Fausto J, Hill D Ashley, Mueller Sabine, Haas-Kogan Daphne A, Phillips Joanna J, Santagata Sandro, Stiles Charles D, Bradner James E, Jabado Nada, Goren Alon, Grill Jacques, Ligon Azra H, Goumnerova Liliana, Waanders Angela J, Storm Phillip B, Kieran Mark W, Ligon Keith L, Beroukhim Rameen, Resnick Adam C
Abstract excerpt
Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, including 19 angiocentric gliomas. We identified MYB-QKI fusions as a specific and single candidate driver event in angiocentric gliomas. In vitro and in vivo functional studies show that MYB-QKI rearrangements promote tumorigenesis through...
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