Article
Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a.
Cancer research - 15 Nov 2010
Shultz Jacqueline C, Goehe Rachel W, Wijesinghe D Shanaka, Murudkar Charuta, Hawkins Amy J, Shay Jerry W, Minna John D, Chalfant Charles E
Abstract excerpt
Increasing evidence points to the functional importance of alternative splice variations in cancer pathophysiology. Two splice variants are derived from the CASP9 gene via the inclusion (Casp9a) or exclusion (Casp9b) of a four-exon cassette. Here we show that alternative splicing of Casp9 is dysr...
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