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Article

A genomic imprinting defect in mice traced to a single gene.

Genetics - 1 Nov 2010

Rentsendorj Altan, Mohan Subburaman, Szabó Piroska, Mann Jeffrey R

Abstract excerpt

Mammalian androgenones have two paternally or sperm-derived genomes. In mice (Mus musculus) they die at peri-implantation due to the misexpression of imprinted genes-the genes that are expressed monoallelically according to the parent of origin. The misexpressions involved are poorly defined. To gain further insight, we examined the causes of midgestation death of embryos with paternal duplication (PatDp) of...

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Identifiers

PMID: 20713691
DOI: 10.1534/genetics.110.118802
PMCID: PMC2975296

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