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Article

A novel polymorphism of the human CD40 receptor with enhanced function.

Blood - 1 Sept 2008

Peters Anna L, Plenge Robert M, Graham Robert R, Altshuler David M, Moser Kathy L, Gaffney Patrick M, Bishop Gail A

Abstract excerpt

CD40 signaling is critical for innate and adaptive immunity against pathogens, and the cytoplasmic domain of CD40 is highly conserved both within and between species. A novel missense single nucleotide polymorphism (SNP) in the cytoplasmic domain of CD40 at position 227 (P227A) was identified, which resides on a conserved ancestral haplotype highly enriched in persons of Mexican and South American descent....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18591382
DOI: 10.1182/blood-2008-02-138925
PMCID: PMC2518891

Genes

BCR
TLR9
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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