Article
Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment
2021-02-03
Abstract excerpt
Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicated in patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed in five mouse models of schizophrenia, bi...
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Identifiers and source
- Literature Corpus work
- e0b33330-43cc-5ed5-86ac-ac4599bf1c19
- DOI
- 10.1101/2021.02.02.428362