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Article

Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility.

Antiviral research - 1 Nov 2021

Chou Sunwen

Abstract excerpt

Acyclovir has weak activity against human cytomegalovirus (CMV). Despite some efficacy as prophylaxis, more potent anti-CMV drugs are preferred. Acyclovir resistance of CMV has been little studied. The viral UL97 kinase phosphorylates acyclovir, and cross-resistance of ganciclovir-resistant mutants is documented. However, UL54 exonuclease domain mutants may confer ganciclovir and cidofovir resistance by a...

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Identifiers

PMID: 34560144
DOI: 10.1016/j.antiviral.2021.105181
PMCID: PMC8578386

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