Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: evidence for age-dependent phenotypes in Pavlovian learning.

Behavioral neuroscience - 1 Dec 2010

Dubroqua Sylvain, Singer Philipp, Boison Detlev, Feldon Joram, Möhler Hanns, Yee Benjamin K

Abstract excerpt

Genetic deletion of glycine transporter 1 (GlyT1) in forebrain neurons gives rise to multiple-procognitive phenotypes, presumably due to enhanced N-methyl-d-aspartate receptor (NMDAR) functions. However, concerns over possible harmful excitotoxic effects under lifelong elevation of synaptic glyci...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Analysis of Variance
Share to Cell Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Classical

Share to Hippocampus

Share to Motor Activity

Share to Prosencephalon

Share to Receptors, N-Methyl-D-Aspartate

Source

Open in PubMed Open full text

Identifiers

PMID: 21038935
DOI: 10.1037/a0021556
PMCID: PMC3000315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21038935-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: evidence for age-dependent phenotypes in Pavlovian learning.PMID 21038935Read ↗

Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile.Semantic proximity Read ↗

Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons.Semantic proximity Read ↗

Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1.Semantic proximity Read ↗

Examining the sex- and circadian dependency of a learning phenotype in mice with glycine transporter 1 deletion in two Pavlovian conditioning paradigms.Semantic proximity Read ↗

Gene knockout of glycine transporter 1: characterization of the behavioral phenotype.Semantic proximity Read ↗

Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: enhanced cognitive adaptability?Semantic proximity Read ↗

Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice.Semantic proximity Read ↗

Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition.Semantic proximity Read ↗

Changes in neural network homeostasis trigger neuropsychiatric symptoms.Semantic proximity Read ↗

Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus.Semantic proximity Read ↗

Excitoprotective effects of conditional tau reduction in excitatory neurons and in adulthoodSemantic proximity Read ↗

Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.