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Article

Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: evidence for age-dependent phenotypes in Pavlovian learning.

Behavioral neuroscience - 1 Dec 2010

Dubroqua Sylvain, Singer Philipp, Boison Detlev, Feldon Joram, Möhler Hanns, Yee Benjamin K

Abstract excerpt

Genetic deletion of glycine transporter 1 (GlyT1) in forebrain neurons gives rise to multiple-procognitive phenotypes, presumably due to enhanced N-methyl-d-aspartate receptor (NMDAR) functions. However, concerns over possible harmful excitotoxic effects under lifelong elevation of synaptic glycine have been raised. Such effects might accelerate the aging process, weakening or even reversing the procognitive...

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PMID: 21038935
DOI: 10.1037/a0021556
PMCID: PMC3000315

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