Article
The l(2)gl homologue of Drosophila pseudoobscura suppresses tumorigenicity in transgenic Drosophila melanogaster.
Oncogene - 1 Jun 1993
Török I, Hartenstein K, Kalmes A, Schmitt R, Strand D, Mechler B M
Abstract excerpt
Mutations in the tumour-suppressor gene lethal(2)giant larvae (l(2)gl) of Drosophila cause malignant transformation of the optic centres of the larval brain and the imaginal discs. We report the cloning and sequencing of the l(2)gl gene from Drosophila pseudoobscura. Comparison of this sequence w...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Base Sequence
- Biological Evolution
- Blotting, Western
- DNA Transposable Elements
- Drosophila
- Drosophila Proteins
- Drosophila melanogaster
- Genes, Tumor Suppressor
- Genetic Variation
- Immunohistochemistry
- Insect Hormones
- Introns
- Molecular Sequence Data
- Neoplasms, Experimental
- Oligodeoxyribonucleotides