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Article

Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation.

Molecular biology of the cell - 1 Aug 2008

Ashok Aarthi, Hegde Ramanujan S

Abstract excerpt

Neurodegeneration in diseases caused by altered metabolism of mammalian prion protein (PrP) can be averted by reducing PrP expression. To identify novel pathways for PrP down-regulation, we analyzed cells that had adapted to the negative selection pressure of stable overexpression of a disease-causing PrP mutant. A mutant cell line was isolated that selectively and quantitatively routes wild-type and various...

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Source

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Identifiers

PMID: 18508914
DOI: 10.1091/mbc.e08-01-0087
PMCID: PMC2488287

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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