Article

Global analysis of protein degradation in prion infected cells

2019-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Prion diseases are rare neurological disorders caused by the misfolding of the cellular prion protein (PrP C ) into cytotoxic fibrils (PrP Sc ). Intracellular PrP Sc aggregates primarily accumulate within late endosomes and lysosomes, organelles that participate in the degradation and turnover of a large subset of the proteome. Thus, intracellular accumulation of PrP Sc aggregates have the p...

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Literature Corpus work: 32db65bd-e720-5383-b69a-19b5dd23e7a9
DOI: 10.1101/712927

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