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Article

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.

The Journal of clinical investigation - 1 Sept 2016

Kratter Ian H, Zahed Hengameh, Lau Alice, Tsvetkov Andrey S, Daub Aaron C, Weiberth Kurt F, Gu Xiaofeng, Saudou Frédéric, Humbert Sandrine, Yang X William, Osmand Alex, Steffan Joan S, Masliah Eliezer, Finkbeiner Steven

Abstract excerpt

Huntington's disease (HD) is a progressive, adult-onset neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the N-terminal region of the protein huntingtin (HTT). There are no cures or disease-modifying therapies for HD. HTT has a highly conserved Akt phosphorylation site at serine 421, and prior work in HD models found that phosphorylation at S421 (S421-P) diminishes the toxicity of mutant...

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Identifiers

PMID: 27525439
DOI: 10.1172/JCI80339
PMCID: PMC5004962

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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