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Article

CASP8 D302H polymorphism delays the age of onset of breast cancer in BRCA1 and BRCA2 carriers.

Breast cancer research and treatment - 1 Jan 2010

Palanca Suela Sarai, Esteban Cardeñosa Eva, Barragán González Eva, de Juan Jiménez Inmaculada, Chirivella González Isabel, Segura Huerta Angel, Guillén Ponce Carmen, Martínez de Dueñas Eduardo, Montalar Salcedo Joaquín, Castel Sánchez Victoria, Bolufer Gilabert Pascual

Abstract excerpt

The polymorphic genetic differences among individuals may modify the high risk for breast cancer (BC) and/or ovarian cancer (OC) susceptibility conferred by BRCA1 and BRCA2 mutations. In the present study we investigate the relevance of RAD51 -135C > G, TP53 R72P, NQO1*2 and CASP8 D302H polymorph...

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Source

Identifiers

PMID: 19214744
DOI: 10.1007/s10549-009-0316-2

Genes

CASP8
BRCA1
BRCA2
NQO1
RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19214744-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CASP8 D302H polymorphism delays the age of onset of breast cancer in BRCA1 and BRCA2 carriers.PMID 19214744Read ↗

Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

Association of two CASP8 polymorphisms with breast cancer risk: a meta-analysis.Semantic proximity Read ↗

Genetic testing of breast and ovarian cancer patients: clinical characteristics and hormonal risk modifiers.Semantic proximity Read ↗

Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant.Semantic proximity Read ↗

A systematic analysis of the association studies between CASP8 D302H polymorphisms and breast cancer risk.Semantic proximity Read ↗

The Difference in Contralateral Breast Cancer and Ovarian Cancer risks for BRCA1 Founder Variant (c.5266dup, c.4035del) Carriers with Primary Breast CancerSemantic proximity Read ↗

CASP8 polymorphisms, estrogen and progesterone receptor status, and breast cancer risk.Semantic proximity Read ↗

The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers.Semantic proximity Read ↗

A common coding variant in CASP8 is associated with breast cancer risk.Semantic proximity Read ↗

The highly prevalent BRCA2 mutation c.2808_2811del (3036delACAA) is located in a mutational hotspot and has multiple origins.Semantic proximity Read ↗

Association of a common variant of the CASP8 gene with reduced risk of breast cancer.Semantic proximity Read ↗

A haplotype containing the p53 polymorphisms Ins16bp and Arg72Pro modifies cancer risk in BRCA2 mutation carriers.Semantic proximity Read ↗

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