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Article

Coevolution within a transcriptional network by compensatory trans and cis mutations.

Genome research - 1 Dec 2010

Kuo Dwight, Licon Katherine, Bandyopadhyay Sourav, Chuang Ryan, Luo Colin, Catalana Justin, Ravasi Timothy, Tan Kai, Ideker Trey

Abstract excerpt

Transcriptional networks have been shown to evolve very rapidly, prompting questions as to how such changes arise and are tolerated. Recent comparisons of transcriptional networks across species have implicated variations in the cis-acting DNA sequences near genes as the main cause of divergence. What is less clear is how these changes interact with trans-acting changes occurring elsewhere in the genetic circuit....

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Identifiers

PMID: 20978140
DOI: 10.1101/gr.111765.110
PMCID: PMC2989993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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