Article
Natural selection on cis and trans regulation in yeasts.
Genome research - 1 Jun 2010
Emerson J J, Hsieh Li-Ching, Sung Huang-Mo, Wang Tzi-Yuan, Huang Chih-Jen, Lu Henry Horng-Shing, Lu Mei-Yeh Jade, Wu Shu-Hsing, Li Wen-Hsiung
Abstract excerpt
Gene expression is regulated both by cis elements, which are DNA segments closely linked to the genes they regulate, and by trans factors, which are usually proteins capable of diffusing to unlinked genes. Understanding the patterns and sources of regulatory variation is crucial for understanding phenotypic and genome evolution. Here, we measure genome-wide allele-specific expression by deep sequencing to...
Topics
- DNA, Fungal
- Evolution, Molecular
- Gene Expression Regulation, Fungal
- Genome, Fungal
- Polymorphism, Single Nucleotide
- Saccharomyces cerevisiae
- Selection, Genetic