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Article

A yeast hybrid provides insight into the evolution of gene expression regulation.

Science (New York, N.Y.) - 1 May 2009

Tirosh Itay, Reikhav Sharon, Levy Avraham A, Barkai Naama

Abstract excerpt

During evolution, novel phenotypes emerge through changes in gene expression, but the genetic basis is poorly understood. We compared the allele-specific expression of two yeast species and their hybrid, which allowed us to distinguish changes in regulatory sequences of the gene itself (cis) from changes in upstream regulatory factors (trans). Expression divergence between species was generally due to changes in...

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Identifiers

PMID: 19407207
DOI: 10.1126/science.1169766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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