Downregulation is the dominant effect of new regulatory mutations in a fungal pathogen.

Abstract excerpt

Well-tuned gene regulation is essential for an organism's survival. However, the ancestral state and predominant effects of regulatory mutations remain poorly understood outside of model fungi, such as Baker's yeast with a highly compact genome organization. Here, we analysed a large panel of genome sequencing data of the major fungal wheat pathogen Zymoseptoria tritici to recapitulate the evolutionary history of...

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