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Article

Functional specialization among insect chitinase family genes revealed by RNA interference.

Proceedings of the National Academy of Sciences of the United States of America - 6 May 2008

Zhu Qingsong, Arakane Yasuyuki, Beeman Richard W, Kramer Karl J, Muthukrishnan Subbaratnam

Abstract excerpt

The biological functions of individual members of the large family of chitinase-like proteins from the red flour beetle, Tribolium castaneum (Tc), were examined by using gene-specific RNAi. One chitinase, TcCHT5, was found to be required for pupal-adult molting only. A lethal phenotype was observed when the transcript level of TcCHT5 was down-regulated by injection of TcCHT5-specific dsRNA into larvae. The larvae...

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Identifiers

PMID: 18436642
DOI: 10.1073/pnas.0800739105
PMCID: PMC2373347

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