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DEGAS: De Novo Discovery of Dysregulated Pathways in Human Diseases

19 Oct 2010

Abstract excerpt

BACKGROUND: Molecular studies of the human disease transcriptome typically involve a search for genes whose expression is significantly dysregulated in sick individuals compared to healthy controls. Recent studies have found that only a small number of the genes in human disease-related pathways show consistent dysregulation in sick individuals. However, those studies found that some pathway genes are affected in...

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PMID: 20976054
DOI: 10.1371/journal.pone.0013367

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