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Article

Translating p53 into the clinic.

Nature reviews. Clinical oncology - 1 Jan 2011

Cheok Chit Fang, Verma Chandra S, Baselga José, Lane David P

Abstract excerpt

Mutations in the TP53 gene are a feature of 50% of all reported cancer cases. In the other 50% of cases, the TP53 gene itself is not mutated but the p53 pathway is often partially inactivated. Cancer therapies that target specific mutant genes are proving to be highly active and trials assessing...

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Source

Identifiers

PMID: 20975744
DOI: 10.1038/nrclinonc.2010.174

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20975744-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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