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Article

IL-6-induced enhancement of c-Myc translation in multiple myeloma cells: critical role of cytoplasmic localization of the rna-binding protein hnRNP A1.

The Journal of biological chemistry - 7 Jan 2011

Shi Yijiang, Frost Patrick, Hoang Bao, Benavides Angelica, Gera Joseph, Lichtenstein Alan

Abstract excerpt

Prior work indicates that IL-6 can stimulate c-Myc expression in multiple myeloma (MM) cells, which is independent of effects on transcription and due to enhanced translation mediated by an internal ribosome entry site in the 5'-UTR of the c-Myc RNA. The RNA-binding protein hnRNP A1 (A1) was also...

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Source

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Identifiers

PMID: 20974848
DOI: 10.1074/jbc.M110.153221
PMCID: PMC3013026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20974848-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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