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Article

Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells.

Oncotarget - 10 Nov 2015

Castellana Bàrbara, Aasen Trond, Moreno-Bueno Gema, Dunn Sandra E, Ramón y Cajal Santiago

Abstract excerpt

Epithelial to mesenchymal transition (EMT) induces cell plasticity and promotes metastasis. The multifunctional oncoprotein Y-box binding protein-1 (YB-1) and the pleiotropic cytokine interleukin 6 (IL-6) have both been implicated in tumor cell metastasis and EMT, but via distinct pathways. Here, we show that direct interplay between YB-1 and IL-6 regulates breast cancer metastasis. Overexpression of YB-1 in...

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Identifiers

PMID: 26512918
DOI: 10.18632/oncotarget.5664
PMCID: PMC4741996

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