Article
Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload.
American journal of physiology. Heart and circulatory physiology - 1 Jan 2011
Symons J David, Hu Ping, Yang Ying, Wang Xiaohui, Zhang Quan-Jiang, Wende Adam R, Sloan Crystal L, Sena Sandra, Abel E Dale, Litwin Sheldon E
Abstract excerpt
Ablating insulin receptors in cardiomyocytes causes subendocardial fibrosis and left ventricular (LV) dysfunction after 4 wk of transverse aortic constriction (TAC). To determine whether these maladaptive responses are precipitated by coronary vascular dysfunction, we studied mice with cardiomyocyte-restricted knock out of insulin receptors (CIRKO) and wild-type (WT) TAC mice before the onset of overt LV...
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