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Article

Loss of insulin receptor substrate-1 signaling induces the cardiovascular and proteo(fibrino)lytic system derangements typical of insulin resistance.

Coronary artery disease - 1 Mar 2005

Furumoto Tomoo, Fujii Satoshi, Onozuka Hisao, Tarikuz Zaman A K M, Goto Daisuke, Sugawara Taeko, Mikami Taisei, Watanabe Satoshi, Abe Kazuhiro, Terauchi Yasuo, Kadowaki Takashi, Kitabatake Akira, Sobel Burton E

Abstract excerpt

BACKGROUND: Type 2 diabetes and insulin resistance have been associated with several cardiac features including diastolic heart failure, impaired ventricular function, perimicrovascular fibrosis and increased expression of plasminogen activator inhibitor type-1 (PAI-1) in coronary arterial walls. Insulin receptor substrate-1 (IRS-1) is one mediator of insulin signaling. This study was performed to determine...

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PMID: 15735405
DOI: 10.1097/00019501-200503000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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