Article
Modulatory effect of the SLC9A3 gene on susceptibility to infections and pulmonary function in children with cystic fibrosis.
Pediatric pulmonology - 1 Apr 2011
Dorfman Ruslan, Taylor Chelsea, Lin Fan, Sun Lei, Sandford Andrew, Paré Peter, Berthiaume Yves, Corey Mary, Durie Peter, Zielenski Julian
Abstract excerpt
In cystic fibrosis (CF), CFTR dysfunction leads to salt and water imbalance across airway epithelia, depleted surface liquid layer, and impaired mucociliary clearance. This provides optimal conditions for chronic bacterial infections leading to excessive inflammation and progressive obstructive lung disease. We hypothesized that other epithelial channels affecting salt balance across the airways may play a role...
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