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Article

Genome-wide association study of susceptibility to Pseudomonas aeruginosa infection in cystic fibrosis.

The European respiratory journal - 1 Nov 2024

Lin Boxi, Gong Jiafen, Keenan Katherine, Lin Fan, Lin Yu-Chung, Mésinèle Julie, Calmel Claire, Mohand Oumoussa Badreddine, Boëlle Pierre-Yves, Guillot Loïc, Corvol Harriet, Waters Valerie, Sun Lei, Strug Lisa J

Abstract excerpt

BACKGROUND: Pseudomonas aeruginosa is a common pathogen that contributes to progressive lung disease in cystic fibrosis (CF). Genetic factors other than CF-causing CFTR (CF transmembrane conductance regulator) variations contribute ∼85% of the variation in chronic P. aeruginosa infection age in CF according to twin studies, but the susceptibility loci remain unknown. Our objective is to advance understanding of...

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Identifiers

PMID: 39117430
DOI: 10.1183/13993003.00062-2024
PMCID: PMC11540985

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