Article
Chloroquine clinical failures in P. falciparum malaria are associated with mutant Pfmdr-1, not Pfcrt in Madagascar.
PloS one - 13 Oct 2010
Andriantsoanirina Valérie, Ratsimbasoa Arsène, Bouchier Christiane, Tichit Magali, Jahevitra Martial, Rabearimanana Stéphane, Raherinjafy Rogelin, Mercereau-Puijalon Odile, Durand Rémy, Ménard Didier
Abstract excerpt
Molecular studies have demonstrated that mutations in the Plasmodium falciparum chloroquine resistance transporter gene (Pfcrt) play a major role in chloroquine resistance, while mutations in P. falciparum multidrug resistance gene (Pfmdr-1) act as modulator. In Madagascar, the high rate of chloroquine treatment failure (44%) appears disconnected from the overall level of in vitro CQ susceptibility (prevalence of...
Topics
- ATP-Binding Cassette Transporters
- Alleles
- Animals
- Antimalarials
- Chloroquine
- DNA, Protozoan
- Drug Resistance
- Gene Dosage
- Madagascar
- Malaria, Falciparum