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Article

Chloroquine clinical failures in P. falciparum malaria are associated with mutant Pfmdr-1, not Pfcrt in Madagascar.

PloS one - 13 Oct 2010

Andriantsoanirina Valérie, Ratsimbasoa Arsène, Bouchier Christiane, Tichit Magali, Jahevitra Martial, Rabearimanana Stéphane, Raherinjafy Rogelin, Mercereau-Puijalon Odile, Durand Rémy, Ménard Didier

Abstract excerpt

Molecular studies have demonstrated that mutations in the Plasmodium falciparum chloroquine resistance transporter gene (Pfcrt) play a major role in chloroquine resistance, while mutations in P. falciparum multidrug resistance gene (Pfmdr-1) act as modulator. In Madagascar, the high rate of chloroquine treatment failure (44%) appears disconnected from the overall level of in vitro CQ susceptibility (prevalence of...

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PMID: 20967251
DOI: 10.1371/journal.pone.0013281
PMCID: PMC2954150

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