Article
Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers.
Neurobiology of aging - 1 Jun 2012
Lau Simon, Bates Kristyn Alissa, Sohrabi Hamid R, Rodrigues Mark, Martins Georgia, Dhaliwal Satvinder S, Taddei Kevin, Laws Simon M, Martins Ian J, Mastaglia Francis L, Foster Jonathan K, Phillips Jacqueline K, Martins Ralph N
Abstract excerpt
A number of genetic risk factors have been identified for Alzheimer's disease (AD) including genes involved in the inflammatory response (interleukin 1A, [IL-1α (-889)], interleukin 1B (IL-1β [+3953]), and tumor necrosis factor (TNF [-308 and -850]). We investigated the prevalence and functional consequences (baseline cognitive performance, plasma cytokine levels) of possession of these putative genetic risk...
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