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Proteomic characterization of Her2/neu‐overexpressing breast cancer cells

3 Sept 2010

Abstract excerpt

The receptor tyrosine kinase HER2 is an oncogene amplified in invasive breast cancer and its overexpression in mammary epithelial cell lines is a strong determinant of a tumorigenic phenotype. Accordingly, HER2-overexpressing mammary tumors are commonly indicative of a poor prognosis in patients. Several quantitative proteomic studies have employed two-dimensional gel electrophoresis in combination with MS/MS,...

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PMID: 20960451
DOI: 10.1002/pmic.201000297

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