Article
Protein expression profiling of primary mammary epithelial cells derived from MMTV-neu mice revealed that HER2/NEU-driven changes in protein expression are functionally clustered.
IUBMB life - 1 Jan 2010
Park Sungwoo, Lee Kyung-min, Ju Ji-hyun, Kim Jaeyoon, Noh Dong-Young, Lee Taehoon, Shin Incheol
Abstract excerpt
MMTV-neu transgenic mice overexpressing NEU in their mammary glands develop tumor after 6 months of age. To find a novel protein biomarker using this mouse model, we identified and characterized the proteins that were differently expressed between primary mammary epithelial cells from 2 months old MMTV-neu heterozygote mice and wild type (WT) littermates using two-dimensional digest (ChemDigest/Trypsin)-LC-MS/MS....
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