Article
NOD2 gene polymorphism rs2066844 associates with need for combined liver-intestine transplantation in children with short-gut syndrome.
The American journal of gastroenterology - 1 Jan 2011
Ningappa Mylarappa, Higgs Brandon W, Weeks Daniel E, Ashokkumar Chethan, Duerr Richard H, Sun Qing, Soltys Kyle A, Bond Geoffrey J, Abu-Elmagd Kareem, Mazariegos George V, Alissa Feras, Rivera Marcus, Rudolph Jeffrey, Squires Robert, Hakonarson Hakon, Sindhi Rakesh
Abstract excerpt
OBJECTIVES: The nucleotide-binding oligomerization protein 2 (NOD2) gene single nucleotide polymorphisms (SNPs) associated with Crohn's disease were recently associated with severe rejection after small-bowel transplantation (SBTx). The purpose of this study was to re-test this association and explore whether deficient innate immunity suggested by the NOD2 SNPs predisposes to intestine failure requiring isolated...
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