Enhanced B Cell Alloantigen Presentation and Its Epigenetic Dysregulation in Liver Transplant Rejection.

doi:10.1111/ajt.13509

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Article

Enhanced B Cell Alloantigen Presentation and Its Epigenetic Dysregulation in Liver Transplant Rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Feb 2016

Ningappa M, Ashokkumar C, Higgs B W, Sun Q, Jaffe R, Mazariegos G, Li D, Weeks D E, Subramaniam S, Ferrell R, Hakonarson H, Sindhi R

Abstract excerpt

T cell suppression prevents acute cellular rejection but causes life-threatening infections and malignancies. Previously, liver transplant (LTx) rejection in children was associated with the single-nucleotide polymorphism (SNP) rs9296068 upstream of the HLA-DOA gene. HLA-DOA inhibits B cell presentation of antigen, a potentially novel antirejection drug target. Using archived samples from 122 white pediatric LTx...

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PMID: 26663361
DOI: 10.1111/ajt.13509
PMCID: PMC5082419

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