Article
Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection.
Gastroenterology - 1 Sept 2008
Sindhi Rakesh, Higgs Brandon W, Weeks Daniel E, Ashokkumar Chethan, Jaffe Ronald, Kim Cecilia, Wilson Patrick, Chien Nydia, Glessner Joseph, Talukdar Anjan, Mazariegos George, Barmada M Michael, Frackleton Edward, Petro Nancy, Eckert Andrew, Hakonarson Hakon, Ferrell Robert
Abstract excerpt
BACKGROUND & AIMS: Limited access to large samples precludes genome-wide association studies of rare but complex traits. To localize candidate genes with family-based genome-wide association, a novel exploratory analysis was first tested on 1774 major histocompatibility complex single nucleotide polymorphisms (SNPs) in 240 DNA samples from 80 children with primary liver transplantation and their biologic parents....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.