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Article

How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance.

Disease models & mechanisms - 1 Jan 2011

Wullschleger Stephan, Sakamoto Kei, Johnstone Lana, Duce Suzanne, Fleming Stewart, Alessi Dario R

Abstract excerpt

The Akt signalling pathway plays vital roles in controlling cellular responses to insulin as well as in proliferation and survival. Inhibition of Akt signalling leads to insulin resistance and type 2 diabetes, whereas hyperactivation of Akt promotes tumorigenesis. In this study, we investigate ho...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Secondary

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to Pyruvate Dehydrogenase Acetyl-Transferring Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 20959631
DOI: 10.1242/dmm.005603
PMCID: PMC3008965

Genes

PDK1
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20959631-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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